CompletedNot Applicable

Obesity and Antibiotic Tissue Concentration

United States31 participantsStarted 2009-06

Plain-language summary

The purpose of this study is to determine whether the dose of prophylactic antibiotics at the time of cesarean delivery requires adjustment in obese and overweight patients in order to achieve optimal antimicrobial activity.

Who can participate

Age range18 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients at term (\> 37 weeks) undergoing a cesarean delivery. Exclusion Criteria: * Women younger than 18 years, * Pre-gestational diabetes, * Chronic hypertension, * Collagen vascular disease, * Multiple gestation, * Contraindications to cefazolin administration (known anaphylactic reaction to penicillins or known cephalosporin allergy), * Any exposure to cephalosporins in one week prior to cesarean section, OR * Need for emergent cesarean delivery or diagnosis of chorioamnionitis.

What they're measuring

To assess the effects of maternal obesity on the concentrations and adequacy of antimicrobial activity of prophylactically administered antibiotics within tissues (subcutaneous adipose and myometrial) at the time of cesarean delivery.

Timeframe: 6 weeks

Trial details

NCT IDNCT00980486

SponsorMemorialCare

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2010-06

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