Phase I STEBVax in Healthy Adults

Inclusion Criteria: * Ability to provide written informed consent. * Age 18 - 40 years, inclusive. * Good "general health" as determined by vital signs (heart rate \<100 bpm; blood pressure systolic \> 90 mm Hg and less than or equal to 140 mm Hg; diastolic \> 50 mm Hg and less than or equal to 90 mm Hg; oral temperature \<100.4 degrees Fahrenheit), medical history, and a physical examination within 45 days before administration of Recombinant Staphylococcal Enterotoxin B Vaccine (STEBVax). Blood pressure outside this range may be repeated once on another occasion. * Expressed interest and availability to fulfill the study requirements * Agrees not to become pregnant from the time of study enrollment until at least 90 days after the last administration of STEBVax; if a woman is sexually active and capable of conception (i.e., no history of hysterectomy or tubal ligation), she must agree to use hormonal or barrier birth control such as implants, injectables, combined oral contraceptives, some intrauterine devices (IUDs), condoms with spermicidal agents, or must have a vasectomized partner, or must be sexually abstinent. A woman is eligible if she is monogamous with a vasectomized male * Agrees not to participate in another clinical trial at any time during the study period. * Agrees to remain in the Baltimore-Washington metropolitan area for 7 days after vaccination. Exclusion Criteria: * History of any of the following medical illnesses: * Toxic shock syndrome * Asthm…