CompletedPhase 2

Spinal Cord Compression Re-Treat Study

Ireland22 participantsStarted 2007-10

Plain-language summary

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Radiation therapy may be effective in treating malignant spinal cord compression in patients who have received previous radiation therapy to the spine. PURPOSE: This phase II trial is studying radiation therapy in treating patients with malignant spinal cord compression.

Who can participate

Age range18 Years – 120 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

DISEASE CHARACTERISTICS: * MRI-confirmed diagnosis of malignant spinal cord compression * MRI of the entire spine performed * Histologically proven malignancy * No primary tumors of the spine or vertebral column * Undergone previous radiotherapy to the involved area of the spinal cord (e.g., full segment and/or ≥ 2 cm in cranio-caudal of overlap between the 2 areas treated) * Maximum biologically effective dose received from previous irradiation ≤ 90 Gy\_2 * Deemed not suitable for neurosurgical intervention at the time of initial assessment * Patients deemed inoperable are eligible PATIENT CHARACTERISTICS: * Karnofsky performance status 40-100% * Short life expectancy * No medical or psychiatric condition that, in the opinion of the investigator or research team, contraindicates participation in this study PRIOR CONCURRENT THERAPY: * See Disease Characteristics

What they're measuring

Response to treatment as assessed by mobility via the Tomita mobility scale

Timeframe: 5 weeks after completion of radiation therapy

Overall response rate (stabilization and response) (stage I)

Timeframe: 5 weeks subsequent to radiation therapy and 3 monthly timepoints thereafter

Trial details

NCT IDNCT00974168

SponsorCancer Trials Ireland

Sponsor typeNETWORK

Study typeINTERVENTIONAL

Primary completion2016-12