Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine

Inclusion Criteria: * Confirmed HIV seropositivity * Permanent residency in the study catchment's area * Confirmed pregnancy, gestational age\< 28 weeks * More than 18 years of age * Karnofsky index ≥80 * Willingness to deliver at the hospital * Written informed consent Exclusion Criteria: * History of allergy to study drugs : sulpha drugs, mefloquine, quinine * History or presence of major illnesses : severe renal disease , severe hepatic disease, severe neuropsychiatric disease * Mefloquine or halofantrine received within the 4 weeks prior to enrolment