CompletedPhase 3

Spinal Cord Compression. ICORG 05-03, V6

Ireland126 participantsStarted 2006-01

Plain-language summary

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy schedule is more effective in treating patients with malignant spinal cord compression. PURPOSE: This randomized phase III trial is studying two different radiation therapy schedules to compare their side effects and how well they work in treating patients with malignant spinal cord compression.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

DISEASE CHARACTERISTICS: * Histologically confirmed malignancy, excluding the following: * Leukemia * Myeloma * Germ cell tumor * Primary tumor of the spine or vertebral column * Diagnosis of malignant spinal cord compression confirmed by MRI of the entire spine * Deemed inoperable or unsuitable for neurosurgical intervention at the time of initial assessment * No single bone metastasis with controlled primary site PATIENT CHARACTERISTICS: * Karnofsky performance status 30-100% * No medical or psychiatric condition that, in the opinion of the investigator or research team, would contraindicate study participation PRIOR CONCURRENT THERAPY: * No prior radiotherapy to the involved area of the spinal cord such that further treatment exceeds spinal cord tolerance

What they're measuring

Mobility status: measured by the change in mobility status between baseline and 5 weeks, as measured by the in-house mobility scale

Timeframe: 5 weeks from date of randomisation

Trial details

NCT IDNCT00968643

SponsorCancer Trials Ireland

Sponsor typeNETWORK

Study typeINTERVENTIONAL

Primary completion2014-05

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