CompletedNot Applicable

Muscle Mass During Space Exploration

United States40 participantsStarted 2009-08

Plain-language summary

The investigators will test the following hypotheses: 1. Bedrest will blunt the anabolic response to a mixed nutrient meal, facilitating a loss of muscle mass and functional capacity that is only partially restored during rehabilitation. 2. Enriching daily meals with leucine will promote protein synthesis and maintain the anabolic response to mixed nutrient meal ingestion. This will preserve lean muscle mass and function during bedrest and facilitate the recovery of functional and metabolic capacity during rehabilitation.

Who can participate

Age range45 Years – 60 Years

SexALL

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Inclusion criteria

✓. Age between 45-60
✓. Ability to sign informed consent

Exclusion criteria

✕. Subjects with cardiac abnormalities considered exclusionary by the study physicians
✕. Subjects with uncontrolled metabolic disease
✕. A GFR \<65 mL/min/1.73m2 or evidence of kidney disease or failure
✕. Subjects with vascular disease or risk factors of peripheral atherosclerosis
✕. Any history of hypo- or hyper-coagulation disorders. (e.g., Coumadin use or history of DVT or PE)
✕. Subjects with chronically elevated systolic pressure \>150 or a diastolic blood pressure \> 100
✕. Subjects with implanted electronic devices (e.g., pacemakers, electronic infusion pumps, stimulators)
✕. Subjects with recently (6 months) treated cancer other than basal cell carcinoma

What they're measuring

Lean Leg Mass

Timeframe: At baseline prior to beginning bed rest and after 14 days of bed rest

Trial details

NCT IDNCT00968344

SponsorThe University of Texas Medical Branch, Galveston

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-04

Results submitted2017-12-01

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