CompletedNot Applicable

To Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-Infection

United Kingdom81 participantsStarted 2009-06

Plain-language summary

This study plans to evaluate what happens to the brain in patients with HIV and early hepatitis C. The investigators will be comparing 3 groups of individuals: * Group 1: Individuals with HIV infection and acute (early) hepatitis C infection * Group 2: Individuals with HIV infection * Group 3: Healthy volunteers

Who can participate

Age range25 Years

SexMALE

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Inclusion criteria

✓. HIV-1 antibody positive for at least 12 months
✓. Acute HCV (Blood HCV PCR positive with negative PCR within past 8 months)
✓. HCV genotype 1
✓. Ability to give informed consent
✓. Aged \> 25 years
✓. Male
✓. Abbreviated Mental Test Score of at least 8/10

Exclusion criteria

✕. Evidence of established cirrhosis or encephalopathy
✕. Commencing or any change to HIV medications within 12 weeks
✕. Active opportunistic infection
✕. Taking anti-depressants or any psychoactive medications within past 4 weeks
✕. Use of benzodiazepines within past 4 weeks
✕. Recent significant head injury
✕. Established dementia
✕. Alcohol dependence or recreational drug misuse

What they're measuring

Association of 11C-labelled PK11195 Uptake Using PET With Acute HCV and HIV Infection

Timeframe: 30 days

Trial details

NCT IDNCT00959166

SponsorImperial College London

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-06

Results submitted2019-09-24

View on ClinicalTrials.gov More Acute Hepatitis C trials