CompletedNot Applicable

Study of Specimens From Young Patients With Neuroblastoma

United States350 participantsStarted 2008-12

Plain-language summary

This research trial studies specimens from young patients with neuroblastoma. Studying the genes expressed in specimens from patients with cancer may help doctors identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of primary Neuroblastoma * Untreated disease * RNA samples from primary untreated NB-tumors available in Children's Oncology Group (COG) repository * At least 60% tumor cells * At least 2 years of follow-up from the date of diagnosis * Full clinical and biological annotation

What they're measuring

mRNA expression levels from genes that have been shown (in at least two independent studies) to have power for outcome prediction in children with NB, assessed by real-time PCR

Timeframe: Baseline

miRNA patterns that have prognostic significance in NB, assessed by a reverse transcription quantitative PCR-based 'stem-loop' method to quantify expression levels

Timeframe: Baseline

Trial details

NCT IDNCT00958659

SponsorChildren's Oncology Group

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2016-05

View on ClinicalTrials.gov More Localized Resectable Neuroblastoma trials