Positron Emission Tomography and Computed Tomography in Planning Treatment for Patients Undergoing 3-Dimensional Conformal Radiation Therapy for Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery. ICORG 06-35

Inclusion Criteria: * Histologically proven (biopsy or cytology) NSCLC (SCC, Adenocarcinoma, Large Cell) * TNM clinical non-operable stage I/II and non-resectable stage IIIa/b without pleural effusion * Measurable disease * No other malignancy, except non-melanomatous skin cancer, within 5 years prior to participation in this study; the disease-free interval from any prior carcinoma must be continuous * Patient suitable for radical 3-DCRT * ECOG-Performance status ≤ 2 / KPS \> or equal to 60 * Weight loss \<10% within the 3 months prior to diagnosis * No prior radiotherapy to the thorax * Patient is suitable for lung-board immobilisation * No chemotherapy received prior to planning PET-CT scan * Age 18 and over * Provision of written informed consent Exclusion Criteria: * Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the trial or if it is felt by the research / medical team that the patient may not be able to comply with the protocol. * FEV1 \< 1