CompletedNot Applicable

Study of the Effects of Iron Levels on the Lungs at High Altitude

Peru33 participantsStarted 2008-10

Plain-language summary

The study hypothesis is that body iron levels are important in determining the increase in lung blood pressure that occurs in response to low oxygen levels. The purpose of this study is to determine whether this is true at high altitude, where oxygen levels are low.

Who can participate

Age range18 Years – 60 Years

SexMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

SLR ARM Inclusion Criteria: * sea level natives of lowland ancestry * generally in good health * detectable tricuspid regurgitation on echocardiography Exclusion Criteria: * any significant medical problem * known susceptibility to high altitude pulmonary or cerebral oedema * taking medications or iron supplements CMS ARM Inclusion Criteria: * diagnosis of chronic mountain sickness * no recent venesection therapy (within 1 year) * detectable tricuspid regurgitation on echocardiography Exclusion Criteria: * any other significant medical problem

What they're measuring

Change in pulmonary artery systolic pressure

Timeframe: One week (SLR arm) and one month (CMS arm)

Trial details

NCT IDNCT00952302

SponsorUniversity of Oxford

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-11

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