UnknownNot Applicable

Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT

China40 participantsStarted 2009-03

Plain-language summary

1. To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors. 2. To validate a pharmacokinetic model which has been established in a formal paper. 3. To create a safe and effective RCA-CRRT protocol.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * healthy individuals, none-pregnant * diagnosed with acute renal failure according to RIFLE criteria * ARF with hepatic insufficiency * ARF with MODS or sepsis * within informed consent Exclusion Criteria: * used drugs with citrate within one week * infused with blood,plasma or platelet or undergone plasma exchange therapy within 48 hours * serious alkalosis with PH\>7.55 * serious lactic acidosis * not in resuscitation state

Trial details

NCT IDNCT00948558

SponsorHuashan Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2010-12

Contact for this trial

Feng Ding, Professor

86-02152888135 ding_feng@hotmail.com

View on ClinicalTrials.gov More Acute Kidney Failure With or Without: trials