CompletedPhase 1/2

Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With Human Menopausal Gonadotropin (HMG) in Polycystic Ovary Syndrome

Iran10 participantsStarted 2009-08

Plain-language summary

The purpose of this study is to compare the effectiveness of low dose human chorionic gonadotropin (HCG) in combination with clomiphen citrate to induce ovulation and its endocrine response in patients who had previously failed to ovulate on clomiphen citrate alone. The investigators will also compare the effectiveness and endocrine response of this approach with the regimen of adding HMG to clomiphen citrate.

Who can participate

Age range18 Years – 30 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women with PCOS diagnosed by the Rotterdam criteria * Previously documented dominant follicle or follicles (R12 mm mean diameter) on transvaginal Ultrasound follicular monitoring while receiving CC at the 150-mg dose in our clinic but have failed to ovulate; * Primary infertility * Documented normal uterine cavity and patent tubes by either hysterosalpingogram or laparoscopy and hysteroscopy; * Male partner had to have a normal semen analysis by World Health Organization criteria. Exclusion Criteria: * previous history of IVF or ICSI treatments. * History of hormonal treatment within recent three month (Except OCP, progesterone). * History of ovarian cutter or Ovarian drilling. * BMI higher than 30. * The presence of ovarian cyst (more than 30 mm) during third cycle ultrasound.

What they're measuring

Multiple pregnancy rates, OHSS rate

Timeframe: Within 20 months after recruiting

Trial details

NCT IDNCT00947713

SponsorRoyan Institute

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2010-08

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