This phase 1/2 trial the studies side effects and best dose of crizotinib and to see how well it works in treating young patients with solid tumors or anaplastic large cell lymphoma that has returned after a period of improvement or does not respond to treatment. Crizotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (Phase 1 completed 2/15/13)
Age range
1 Year – 21 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Maximum-tolerated Dose and Recommended Phase 2 Dose of Crizotinib
Timeframe: 28 days
Number of Participants With Toxicities of Crizotinib
Timeframe: Up to 30 days post-treatment
Steady State C Max of Crizotinib
Timeframe: Cycle 1 (day 15- 28) pre-dose, 1, 2,4, 6-8 hours post dose
Steady State C Average of Crizotinib
Timeframe: Cycle 1 (day 15-28) pre-dose, 1, 2, 4, 6-8 hours post-dose
Steady State AUC of Crizotinib
Timeframe: Cycle 1 (day 15-28) pre-dose, 1, 2, 4, 6-8 hours post-dose
Steady State Clearance of Crizotinib
Timeframe: Cycle 1 (day 15-28) pre-dose, 1, 2, 4, 6-8 hour post-dose