This phase 1/2 trial the studies side effects and best dose of crizotinib and to see how well it works in treating young patients with solid tumors or anaplastic large cell lymphoma that has returned after a period of improvement or does not respond to treatment. Crizotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (Phase 1 completed 2/15/13)
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Maximum-tolerated Dose and Recommended Phase 2 Dose of Crizotinib
Timeframe: 28 days
Number of Participants With Toxicities of Crizotinib
Timeframe: Up to 30 days post-treatment
Steady State C Max of Crizotinib
Timeframe: Cycle 1 (day 15- 28) pre-dose, 1, 2,4, 6-8 hours post dose
Steady State C Average of Crizotinib
Timeframe: Cycle 1 (day 15-28) pre-dose, 1, 2, 4, 6-8 hours post-dose
Steady State AUC of Crizotinib
Timeframe: Cycle 1 (day 15-28) pre-dose, 1, 2, 4, 6-8 hours post-dose
Steady State Clearance of Crizotinib
Timeframe: Cycle 1 (day 15-28) pre-dose, 1, 2, 4, 6-8 hour post-dose