Botulinumtoxin A Treatment in Epidermolysis Bullosa Simplex and Pachyonychia Congenita

Inclusion Criteria: * Informed consent received from patient * Informed consent received from patient´s parents (when patient \< 18 years) * A solid EBS-diagnosis based on genetic analysis and/or phenotype. The EBS-diagnosis will be performed by Professor Anders Vahlquist, Swedish Centre of Genetic skin disorders, Uppsala. * Age \> 16 years * Patients must be previously untreated with Btx A * If female, patient is post-menopausal, surgically sterilized, or willing to use an acceptable method of birth control Exclusion Criteria: * Contraindication to Btx A * Contraindication to general anaesthesia * Use of aminoglycosides, tetracyclines , spectinomycin, lincomycin, polymyxin or muscle relaxants * Pregnancy or lactation * Patients unwilling to meet the requirements of the protocol * Other medical or social reasons for exclusion at the discretion of the Investigator