Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone

Inclusion Criteria: * Early to midpubertal girls (late Tanner 1 \[i.e., estradiol \> 20 pg/ml\] to Tanner 3) * Premenarcheal * Approximate ages, 8-15 years Exclusion Criteria: * BMI-for-age \< 5th percentile * Inability to comprehend what will be done during the study or why it will be done * Being a study of GnRH pulse regulation in adolescent girls with and without HA, boys are excluded * Obesity associated with a diagnosed (genetic) syndrome (e.g., Prader-Willi syndrome, leptin deficiency), obesity related to medications (e.g., glucocorticoids), etc. * Pregnancy or lactation * Virilization * Total testosterone \> 150 ng/dl (confirmed on repeat) * DHEAS \> upper limit of age-appropriate normal range (confirmed on repeat) (mild elevations may be seen in adolescent HA, and elevations \< 1.5 times the age-appropriate upper limit of normal will be accepted in such girls) * Follicular phase 17-hydroxyprogesterone \> 250 ng/dl (for girls \< 12 years old) or \> 300 ng/dl (for girls 12 and older) (confirmed on repeat), which suggests the possibility of congenital adrenal hyperplasia. NOTE: If an elevated follicular 17-hydroxyprogesterone is confirmed on repeat testing, an ACTH stimulated 17-hydroxyprogesterone \< 1000 ng/dl will be required for study participation * History of premature adrenarche (i.e., appearance of pubic and/or axillary hair before age 8) * A previous diagnosis of diabetes * Fasting glucose ≥ 126 mg/dl, or a hemoglobin A1c \> 6.5% (confirmed on repeat) * Abno…