Biology Studies of Hematologic Cancers (NCT00923442) | Clinical Trial Compass
By InvitationNot Applicable
Biology Studies of Hematologic Cancers
United States550 participantsStarted 2004-02-24
Plain-language summary
This study will collect tumor samples from people with cancers of the blood, bone marrow, or lymph glands for laboratory study of the biology of these conditions. Such studies contribute to a better understanding of cancer biology and to the development of new treatments. Planned studies include:
* Examination of individual cancer cells and to search for differences compared to other types of cancer and normal cells
* Examination of the chromosomes and genes in cancer cells and to search for differences compared to other types of cancer and normal cells
* Development of sensitive methods to detect small amounts of cancer that remain after treatment
* Search for new cancer proteins that might serve as targets for treatment
* Investigation of methods to develop cancer vaccines.
Patients from \>= 1 to 75 years of age with acute lymphocytic leukemia, acute myelogenous leukemia, myelodysplastic syndrome, chronic myelogenous leukemia, juvenile myelomonocytic leukemia, non-Hodgkin's lymphoma, Hodgkin's disease, and other hematologic malignancies may be eligible for this study.
Blood or bone marrow samples will be collected when sampling is required for the patient's medical care. Cells from some individuals will be grown in test tubes, establishing cell lines or in animals, establishing xenograft models. (A xenograft is transplantation of cells of one species to another species.)
Who can participate
Age range
1 Year – 120 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* INCLUSION CRITERIA
Confirmed pathological diagnosis of any hematologic malignancy or pre-malignant blood disorder, including but not restricted to the following:
Acute Lymphocytic Leukemia (ALL)
Acute Myelogenous Leukemia (AML)
Myelodysplastic Syndrome (MDS)
Chronic Myelogenous Leukemia (CML)
Juvenile Myelomonocytic Leukemia (JMML, J-CML)
Non-Hodgkin's Lymphoma (NHL)
Hodgkin's Disease
Tumor tissue that has been previously collected and is available for study or that can be collected with minimal additional risk to the subject during sampling required for routine patient care.
Age: \>= 1 years.
Prior therapy: no restrictions
Subject, parent/guardian, legally authorized representative (LAR), or durable power of attorney must be able to give informed consent and sign the informed consent document.
EXCLUSION CRITERIA
None
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this study is focused on collecting tissue samples for lab research rather than testing a treatment, what would actually happen to my samples and how might that research eventually benefit people with my specific diagnosis — for example, acute leukemia or lymphoma?
2This trial is 'enrolling by invitation only' — how would my doctor decide to invite me, and does participating in this biology study have any connection to or effect on my actual treatment plan?
3Because this is listed as 'Phase NA,' meaning it's a laboratory research study rather than a treatment trial, what are the real-world risks to me personally of donating tissue or blood samples for this kind of study?
4Are there standard diagnostic biopsies or blood draws I'm already having that could be used for this study, or would I need to undergo additional procedures specifically for the research?
5If I participate in this biology study, does that affect my eligibility to join other clinical trials in the future that might offer a new treatment for my condition?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.