Implications of Amyloid Pathology

Inclusion Criteria: * Age range from 60 to 90 years * Clinical Dementia Rating (CDR) Score of 0 * Mini Mental State Exam of 27-30 * A study partner who can answer questions pertaining to daily functioning * Perform within 1.5 standard deviation of age and education matched norms on screening tests of attention and executive function, language, visuospatial perception and episodic memory * Stable medications for at least 30 days * Fluent in English * Modified Hachinski Score of \<4 * Geriatric Depression Scale Score \<10 Exclusion Criteria: * Diagnosis of MCI or dementia * Individuals with contraindications to MRI (i.e., implanted metal including pacemakers, cerebral spinal fluid shunts, aneurysm clips, artificial heart valves, ear implants or metal/foreign objects in the eyes and those with a history of claustrophobia) * Unstable medications or on medications with CNS effects including cholinesterase inhibitors, memantine, and antidepressants * Major psychiatric disorders such as schizophrenia, schizoaffective disorder, major affective disorder, or treatment with ECT (mild depression that is well treated with stable dose of SSRI antidepressants will be allowed) * Multiple sclerosis or other autoimmune disorders * Huntington's disease * Head injury, post-traumatic dementia or seizures * Metabolic encephalopathy, CNS infection, hydrocephalus * Cardiovascular disease, stroke, congestive heart failure * Substance abuse within the past 2 years * Active cancer * Active hematolog…