RATIONALE: Analyzing tissue and blood samples from healthy volunteers or patients with Fanconi anemia, myelodysplasia, myeloproliferative disorders, or myeloma in the laboratory may help doctors learn more about the causes of blood cancers. PURPOSE: The purpose of this study is to analyze in the laboratory blood and bone marrow cells from healthy volunteers or patients with Fanconi anemia, myeloproliferative disorders, or myeloma.
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Loss of function analyses
Timeframe: Duration of the study
Proteins binding to Fanconi anemia, complementation group C (FACC) gene-product by affinity chromatography of nuclear and whole cell lysates of normal cells
Timeframe: Duration of the study
Screening of proteins binding to FACC gene-product using monoclonal antibodies specific to signal transduction and cell cycle proteins
Timeframe: Duration of the study
Microsequencing of unique proteins
Timeframe: Duration of the study
Location of specific downstream block point imposed by antisense molecules using antibodies specific to signal transduction, cell cycle, or repair proteins for the FACC protein
Timeframe: Duration of the study
Affirmation that the block points identified are recapitulated in progenitor cells from peripheral blood
Timeframe: Duration of the study
Identification of functional defects in Fanconi anemia hematopoietic stromal cells
Timeframe: Duration of the study