Collecting and Storing Tissue From Young Patients With Cancer (NCT00898755) | Clinical Trial Compass
CompletedNot Applicable
Collecting and Storing Tissue From Young Patients With Cancer
United States, Canada213 participantsStarted 2007-03-05
Plain-language summary
This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
Who can participate
Age range
21 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* All malignant tissues from childhood cancers allowed including the following:
* Brain tumors (all types)
* Tissue should be submitted to CNS Committee Resource labs to be forwarded for this study, unless instructed otherwise on the COG web site
* Ewing family of tumors
* Rhabdomyosarcomas
* Other soft tissue sarcomas
* Osteogenic sarcomas
* Rhabdoid tumors
* Neuroblastomas
* Viable material for cell culture for neuroblastoma is collected via COG-ANBL00B1 and should not be submitted via this study unless the patient cannot be enrolled on COG-ANBL00B1\*
* Retinoblastomas
* Anaplastic Wilms tumor
* Germ cell tumors
* Leukemias/lymphomas
* Acute myeloid leukemia (AML)
* Blood samples and bone marrow samples from patients at second relapse and beyond may be submitted for this study
* Bone marrow samples at diagnosis or first relapse must be submitted to an AML resource lab and will be forwarded for this study at the discretion of the AML Committee
* Acute lymphoblastic leukemia (ALL)
* Blood samples may be submitted directly to this study
* Bone marrow samples must be submitted to an ALL resource lab and will be forwarded for this study at the discretion of the ALL Committee
* Enrolled on a COG therapeutic, biology, or tissue banking protocol that allows collection of tissue for research and submission to a COG-designated resource laboratory
* Participation in this protocol is not permitt…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Establishment and banking of cell lines and/or xenografts from pediatric patients with cancer
Timeframe: Up to 14 years
2
Establishment of continuous cell lines, under carefully controlled conditions, from pediatric patients with cancer
Timeframe: Up to 14 years
3
Establishment of transplantable xenografts in immunocompromised mice from tumor cells that are difficult to establish as continuous cell lines in vitro
Timeframe: Up to 14 years
4
Creation of a bank of cell lines and generation of sufficient vials of cryopreserved cells for distribution to investigators with approved COG biology protocols
Timeframe: Up to 14 years
5
Characterization of cell lines from childhood cancers with respect to DNA PCR molecular HLA profile as a "fingerprint" of original cell line identity
Timeframe: Up to 14 years
6
Characterization of cell lines for the ability for sustained growth in tissue culture and/or as mouse xenografts
Characterization of cell lines for mycoplasma contamination
Timeframe: Up to 14 years
8
Characterization of cell lines for expression of molecular makers that confirm the tumor-type of the cell line and the immortal nature of the cells (telomerase) and the expression of molecular markers that may correlate with drug resistance