Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma

Inclusion criteria

• ✓. A histologically documented World Health Organization (WHO) grade I, II, or III meningioma, newly diagnosed or recurrent, and of any resection extent, confirmed by central pathology review. Patients are partitioned according to three groupings: Group I (low risk), Group II (intermediate risk), and Group III (high risk) as defined below:
• ✓. History/physical examination, including neurologic examination, within 8 weeks prior to Step 2 registration
• ✓. Zubrod Performance Status 0-1
• ✓. Age ≥ 18
• ✓. All patients must have a magnetic resonance imaging (MRI) scan within 12 weeks prior to Step 2 registration. Both preoperative and postoperative MRIs are required for all newly diagnosed patients in groups I, II, or III. In the setting of group II or III patients with recurrent/progressive meningioma and without recent surgery, a pre-operative study may not apply, although MRI documentation of recurrence or progression is required. MRIs must include precontrast T1, T2, and flair images and multiplanar (axial, sagittal, and coronal) postcontrast T1. The postoperative study must be completed within 12 weeks of surgery.
• ✓. For woman of childbearing potential who are intermediate or high risk:
• ✓. Patient must sign study-specific informed consent prior to study entry

Exclusion criteria