Photosensitivity Proof of Concept Trial

Inclusion Criteria: * Male or female age 18-60 years. * A diagnosis and history of a photoparoxysmal response on EEG with or without a diagnosis of epilepsy for which patients are on 0-1 concomitant antiepileptic drugs. * A reproducible IPS-induced photo-paroxysmal response (PPR) on EEG of at least 3 points on a frequency assessment scale in at least one eye condition and no change of more than 3 frequencies in 2 repeated measurements recorded at screen in at least one eye condition. * Patients in otherwise good health (with the exception of epilepsy), as determined by the PI via the medical history, a physical examination and screening laboratory investigations. * A body mass index (BMI) between 18 and 35. * Able and willing to provide written informed consent to participate in the study in accordance with the ICH, GCP guidelines. Exclusion Criteria: * A history of non epileptic seizures (e.g. metabolic, structural or pseudo-seizures). * Women who are pregnant or lactating. * Women of reproductive potential who do not agree to use effective birth-control methods. * Any clinically significant laboratory abnormality which, in the opinion of the investigator, will exclude the patient from the study. * An active CNS infection, demyelinating disease, degenerative neurological disease or any CNS disease deemed to be progressive during the course of the study that may confound the interpretation of the study results. * Any clinically significant psychiatric illness, psychologica…