Effects of Propranolol on the Encoding and Retrieval of Emotional Material After Single Dose Administration in Healthy Young Subjects

Inclusion Criteria: * age: 18 - 35 years * sex: male * ethnic origin: Caucasian * body weight: between 19 kg/m² and 27 kg/m² \[calculated from weight (kg)/height2 (m2)\] * good health as evidenced by the results of the clinical examination, ECG, and laboratory check-up, which are judged by the clinical investigator not to differ in a clinical relevant way from the normal state * written informed consent Exclusion Criteria: * obstructive lung disease (e.g. bronchial asthma) * peripheral arterial circulatory disturbance * any disturbance of impulse formation and conduction (e.g. sick sinus syndrome, SA or AV-blockade) * bradycardia (\< 50 beats/min) * hypotension (systolic pressure \< 90 mmHg) * existing cardiac or hematological diseases and/or pathological findings, which might interfere with the drug's safety, tolerability, absorption and/or pharmacokinetics * existing hepatic and renal diseases and/or pathological findings, which might interfere with the drug's safety, tolerability, absorption and/or pharmacokinetics * existing gastrointestinal diseases and/or pathological findings, which might interfere with the drug's safety, tolerability, absorption and/or pharmacokinetics * existing or further diseases of the CNS, especially epilepsy * acute or chronic diseases which could affect absorption or metabolism * history of any serious psychological disorder * taking MAO inhibitors * drug or alcohol dependence * positive drug or alcohol screening * smokers * positive anti-HI…