Efficacy Study of Vaginal Mifepristone to Treat Uterine Fibroids

Inclusion Criteria: * Uninterested in fertility during the study. * Premenopausal status. * Active symptoms related to uterine fibroids. * Subjects will be obligated to use non hormonal contraceptives during the study. Exclusion Criteria: * Abnormal liver and renal function * Participants with significant increase in uterine fibroids size during a short time. * Exclusionary health problems contraindicating mifepristone included adrenal disease; sickle cell anemia; severe liver, respiratory, or renal disease; and blood clotting defect. * Current use of steroids, anticoagulants, herbals, or botanicals with possible hormonal effects.