CompletedNot Applicable

Sublingual Milk Immunotherapy in Children

France51 participantsStarted 2008-09

Plain-language summary

Sublingual immunotherapy is developing in the treatment of aeroallergens allergy. The hypothesis is that such process may be applied to food allergy, more precisely to milk. A previous series of 8 patients indicates the likely effectiveness of this technique (Allergy, 2006).

Who can participate

Age range5 Years – 17 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Children, male and female * Children \> 5 years * Children with IgE-mediated cow milk allergy, with detectable specific IgE (\> 0.10 KU/l) and an immediate type reaction during oral provocation test for a cumulated dose \< 100 mL of milk). * Children and parents or tutors having given their informed consent after complete information Exclusion Criteria: * Children participating or having already participated to a drug trial during the 3 preceding months * Children with immune deficiency * Children with disabling disease, preventing from a correct practice of sublingual treatment * Children receiving steroid therapy * Children refusing to participateSevere food neophobia * Reaction to placebo during the double blind oral provocation test * Severe anaphylactic reaction with milk during the 6 preceding months

What they're measuring

Reactive milk dose at inclusion, at 6 months and at 12 months

Timeframe: at inclusion, at 6 months and at 12 months

Trial details

NCT IDNCT00874627

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-09

View on ClinicalTrials.gov More Cow Milk Allergy trials