UnknownPhase 3

Torsion Optimization to Reduce Symptoms and Improve Outcomes in Non-responders

Canada60 participantsStarted 2009-03

Plain-language summary

Approximately 40% of resynchronization therapy recipients do not appear to clearly benefit. These patients are termed 'non-responders'. This study will assess whether a heart ultrasound (echo) technique called 'torsion imaging' can be used to increase the likelihood of benefit from resynchronization therapy.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * non-response to CRT as indicated, * stable doses of ACE I / ARB and beta-blocker for ≥ 2 months, \& * controlled heart rate if in atrial fibrillation. Exclusion Criteria: * inadequate images to assess torsion * no significant augmentation in torsion with optimization * unable or unwilling to provide informed consent, * medical condition other than HF likely to cause death within 6 months, * cardiac transplant planned, * myocardial infarction or revascularization since CRT implant.

What they're measuring

Improved functional class (≥ 1 class) & remodeling (either ≥ 10% relative reduction in LV ESV or a ≥ 5% absolute increase in LV EF).

Timeframe: Follow up (3-6 months) versus baseline.

Trial details

NCT IDNCT00867984

SponsorUniversity of Calgary

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12

View on ClinicalTrials.gov More Heart Failure, Congestive trials