Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis.

Indication and Criteria for Inclusion/Exclusion: Subjects who are to be included in the study have to meet all of the following criteria: * Informed consent * Male and female, age over 18 years * Solid tumour neoplastic meningitis as demonstrated by a positive lumbar CSF cytology (obtained within 21 days prior to treatment initiation) OR Characteristic signs and symptoms of neoplastic meningitis PLUS an MRI indicating the presence of meningeal tumour (diagnosis to be made by neuro-oncologist and confirmed / signed within the CRF). All MRIs will be forwarded for central review and confirmation of diagnosis. In case of discrepancy the central review overrides the assessment of the investigator. * CSF flow abnormality excluded by either an MRI scan or a 99Tc-DTPA or 111In-DTPA flow study. (If a flow abnormality is initially demonstrated but the flow block is subsequently documented by another flow study or MRI scan to be relieved following limited field radiation therapy, the subject may then be eligible) * If brain metastasis confirmed (including subjects who have had previous stereotactical radiosurgery or solitary lesion brain surgery) the lesion should be less than 3cm diameter * Mini Mental State Examination (MMSE) score more than 24 * ECOG performance status 0-2 Laboratory values as follows: * Platelet count more than or equal to 80,000/mm3 * ANC more than or equal to 1,000/mm3 * Serum creatinine less than or equal to 2 x upper limit of normal * Total bilirubin less …