CompletedPhase 4

Treatment Trial for Psychogenic Nonepileptic Seizures

United States38 participantsStarted 2008-09

Plain-language summary

The investigators propose that patients who receive targeted pharmacotherapy (sertraline) or focused psychotherapy (cognitive behavioral therapy-informed psychotherapy (CBT-ip) for NES) or combined treatment (CBT-ip + sertraline) will report fewer nonepileptic seizures (NES) compared to patients who receive community care / treatment as usual (TAU). The purpose of this study is to provide pilot testing and data to inform the future multicenter randomized controlled trial based on the hypothesis.

Who can participate

Age range18 Years – 95 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Video electroencephalogram (EEG) confirmed diagnosis of NES * Have at least one nonepileptic seizure per month * Able to complete self report symptom scales * Not receiving optimized sertraline Exclusion Criteria: * Equivocal EEG findings * using monoamine oxidase inhibitors (MAOIs), pimozide, or sumatriptan * allergy/sensitivity to sertraline * current alcohol/drug dependence * serious medical illness requiring current hospitalization

What they're measuring

seizure frequency

Timeframe: weekly

Trial details

NCT IDNCT00835627

SponsorRhode Island Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-12

View on ClinicalTrials.gov More Convulsion, Non-Epileptic trials