A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.

Inclusion Criteria: * Port wine stain suitable for comparison testing. * Age \> 13 years of age or older; minor will be accompanied in the room by parents or guardians during laser treatment. * Apparent good health as documented by medical history. * Ability to understand and carry out subject instructions. * Women of childbearing potential must have a negative urinary pregnancy test prior to being started on rapamycin. * Women of child bearing potential must agree to use a medically acceptable method of contraception throughout the study and for 3 months following discontinuation of rapamycin. Exclusion Criteria: * Inability to understand and carry out instructions. * Pregnancy. * Abnormal blood or urine tests * History of cancer. * History of high cholesterol, lipids or liver disease. * Allergy to macrolide drugs (e.g., erythromycin). * Any therapy within the previous two months to the proposed port wine stain treatment sites. * Current participation in any other investigational drug evaluation. * Concurrent use of known photosensitizing drugs. * Concurrent use of immunosuppressive drugs or steroids. * Concurrent use of any of the following medications: antifungals, antiepileptics, protease inhibitors, cimetidine, cisapride, clarithromycin, dannzol, diltiazem, erythromycin, metoclopramide, rifabutin, rifampin, rifapetine, troleandomycin, or verapamil.