Therapeutic Treatment With Human Papillomavirus Quadrivalent Vaccine for Recurrent Respiratory Papillomatosis

Inclusion Criteria: * There are 9 participants currently being followed in the faculty sponsor's clinic that carry the clinical and histologic diagnosis of RRP. The 9 participants meet one or more of the following criteria: Surgery requirement of more than 4 procedures per year, distal multisite spread of disease, and rapid regrowth of papilloma disease with airway compromise. Exclusion Criteria: * If any of the 9 patients meet the following criteria they will be excluded from the study: * Pregnancy * Hypersensitivity or allergy to vaccine components (i.e. Saccharomyces cerevisiae yeast) * Immunocompromised patients (i.e. patients with HIV, cancer, or who take immunosuppressant medications including all forms of steroids) * Have a fever over 100°F (37.8°C) * Moderate or severe acute illness (with or without fever) * Coagulopathies * Platelet counts of less than 100,000 * Any history of recent treatment(within 3 months) with any investigational drug or other adjuvant RRP therapy (including interferon-gamma, ribavirin, acyclovir, cidofovir and photodynamic therapy, indole-3-carbinol)