RecruitingNot Applicable

Evaluation of Patients With Non-obstructive Coronary Arteries

United States2,000 participantsStarted 2007-06

Plain-language summary

Patients with angina and non-obstructive CAD are common within clinical practice, but remain a challenge with regard to diagnosis and treatment. When these patients undergo a comprehensive evaluation at the time of invasive coronary angiography, occult coronary abnormalities are frequently found. We hope to learn the overall prevalence and presentation of these occult coronary abnormalities and its long term outcome in this patient population.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Patient referred for elective coronary angiography because of a reasonable clinical suspicion of coronary ischemia.
✓. Presence of angina or an anginal equivalent (including chest, back, shoulder, arm, neck, jaw discomfort, or shortness of breath brought on by physical exertion, emotional stress, or certain times of day/month).

Exclusion criteria

✕. Asymptomatic (such as a pre-op cath)
✕. Status-post heart transplant
✕. Age \<18
✕. Renal insufficiency (creatinine \>1.5)
✕. Presence of an acute coronary syndrome (STEMI or NSTEMI), Tako-tsubo, an abnormal ejection fraction (EF\<55%), cardiogenic shock, or recent VT/VF
✕. Presence of another likely explanation of chest pain, such as pulmonary hypertension or aortic stenosis
✕. History of adverse reaction to any of the medications being used (acetylcholine, nitroglycerin, adenosine, or heparin)
✕. Currently taking vasoactive medication (such as nitroglycerin)

What they're measuring

Sex Differences in Endothelial Dysfunction, Microvascular Dysfunction, and Diffuse Plaque

Timeframe: Day of procedure (study day one)

Number of participants with major adverse cardiovascular events (MACE)

Timeframe: 15 years

Trial details

NCT IDNCT00823563

SponsorStanford University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2047-06

Contact for this trial

Vedant Pargaonkar, MD

(650) 498-1195 vedantsp@stanford.edu

View on ClinicalTrials.gov More Chest Pain trials