Use of Antithrombin in Cardiac Surgery With Cardiopulmonary Bypass

Inclusion Criteria: * Male or female * At least 18 years of age * Subject needed elective cardiac surgery with cardiopulmonary bypass except for heart transplantation * Subject had a baseline ATIII level of less than 100% and equal to or above 60% * Subject signed the informed consent form * Subject was willing to comply with all aspects of the protocol, including blood sampling, for the total duration of the study Exclusion Criteria: * Documented congenital ATIII deficiency or ATIII levels below 60% * Subject had a baseline ATIII level of 100% or higher * Subject needed emergency (non-elective) surgery * Subject needed heart transplantation * History of anaphylactic reaction(s) to blood or blood components * Allergies to excipients * Subject was pregnant * Subject had any medical condition that according to the investigators judgment worsens the surgical outcome above the expected * Subject had any medical condition which is likely to interfere with the evaluation of the study treatment and/or the satisfactory conduct of the trial according to the investigators judgment * Subject had participated in any another investigational study within the last 30 days previous to the inclusion