CompletedNot Applicable

MRI Markers of Cartilage Damage in Knee With Osteoarthritis

United States53 participantsStarted 2006-11

Plain-language summary

The objectives of this study are: to identify and develop techniques to minimize precision errors in magnetic resonance imaging (MRI) evaluation of knee cartilage, and to determine if results from newly-identified MRI techniques in measuring cartilage changes and structure can be reproduced.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participants must be \>18 years old; * Participants must have a KL score between 0 and 3; * Participants must have clearance to use protocol specified equipment: 3T MRI with parallel imaging capability and phased array knee coil (minimum 4 elements); * Participant had no change of treatment occur within the last 6 months; * Participants have no plans of changing to a different treatment within the next 3 months; * Participant must provide a study-specific signed informed consent form. Exclusion Criteria: * Patients with contraindication to 3T MRI: Claustrophobia, Implanted metal or medical device that is not approved for MRI scanning at 3T, pregnancy, inability to tolerate relative immobility for 1 hour; * Patients with prior knee surgery or trauma of the knee; * Patients with KL score of 4.

What they're measuring

The primary study goals are to develop and evaluate MRI techniques that minimize systematic errors in measuring knee cartilage, and to assess the reproducibility of MRI techniques comparing normal and osteoarthritic knees across institutions.

Timeframe: 4 sequental MRI evaluations of the target knee within a 4-week period

Trial details

NCT IDNCT00820430

SponsorAmerican College of Radiology

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2008-05

View on ClinicalTrials.gov More Osteoarthritis, Knee trials