Effect of Vecam 40/300 and Vecam 20/300 Compared to Omeprazole 20 mg on Gastric pH

Inclusion Criteria: * Healthy, H. pylori negative status (by Urea Breath Test) * Male or female subjects * Age 18-55 years * Able to tolerate the placement of a nasogastric pH probe at screening * Baseline Gastric pH≤2 * Use of acceptable form of birth control in females with child-bearing potential * Had not used any form of tobacco (e.g. smoking or chewing) for the last year * Can swallow a size "00" capsule without difficulty * Willing to comply with study protocol * Signed Informed Consent form Exclusion Criteria: * BMI \> 40 * Slow or poor Omeprazole metabolizers (heterozygous or homozygous, respectively) based on CYP2C19 genotyping test. * Any significant history of / or concurrent gastrointestinal diseases or conditions such as: * GERD * Acute gastrointestinal bleeding * Zollinger Ellison Syndrome or Gastric hypersecretory condition * Known Barrett's esophagus * Esophageal stricture * Peptic ulcer disease (gastric or duodenal) or family history of peptic ulcer disease * Gastric outlet obstruction * Gastroparesis * Significant medical history or concurrent illness as determined by the principal investigator * Any medical disorder that alters the normal gastric acid secretion profile as determined by the principal investigator * History of diabetes mellitus * Significant laboratory abnormalities as determined by the principal investigator * Known metabolic alkalosis, hypocalcemia, sodium restricted diet, hypokalemia, respiratory alkalosis * Pregnant o…