Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI) (NCT00810368) | Clinical Trial Compass
CompletedPhase 2
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
United States33 participantsStarted 2008-08
Plain-language summary
The purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 GWI subjects.
Who can participate
Age range
34 Years – 82 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Evidence of military enlistment between August 1, 1990 and July 31, 1991, and deployment for 30 consecutive days to:
* Persian Gulf waters and adjacent land areas,
* Other global locations, or,
* U.S. only. 1990-1991 enlistment status:
* Active duty
* National Guard
* Reserves
Exclusion Criteria:
* HIV/AIDS
* Pregnant Women
* Active Duty Military Personnel
* Children
* Incarceration
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Effect of Carnosine Supplementation on Chronic Fatigue Syndrome Severity Scores
Timeframe: Weeks 0 and 12
2
Subjects With Improved Diarrhea Symptoms
Timeframe: Weeks 0 and 12
3
Incremental Change in Fatigue Score From Baseline to Week 12
Timeframe: Week 0 and Week 12
4
SF36 Bodily Pain
Timeframe: Week 0 and Week 12
5
Incremental Change in Generalized Anxiety Scale (GAD) Scores From Baseline to Week 12
Timeframe: Week 0 and Week 12
6
Incremental Change in SF36 General Health Between Baseline and Week 12