C-Cure Clinical Trial

Inclusion Criteria: * Subject is ≥ 18 and \< 75 years old; * Subject has Heart Failure, New York Heart Association (NYHA) class II or class III with LVEF \> 15% and ≤ 40% as assessed by transthoracic echocardiography; * Subject has ischemic heart disease; * Subject has an identifiable (by transthoracic echocardiography) area of transmural scar within the left ventricle; * Subject is on optimal and stable medical therapy for more than 2 months; * Subject is willing and able to undergo an ICD implantation, prior to receiving C-Cure™ or already has an ICD implanted; * Subject agrees to comply with all follow-up evaluations; * Subject has been informed of the nature of the clinical trial and agrees to its provision and has provided written informed consent. Exclusion Criteria: * Subject has been treated with cell-based therapy; * Subject has myocardial revascularization by PCI or CABG within 2 months prior to enrolment; * Subject has had an MI within 2 months prior to enrolment; * Subject is planned for PCI, CABG or any cardiac surgery; * Subject has received a biventricular pacemaker within 6 month prior to enrolment; * Subject has moderate to severe aortic valve heart disease, aortic or mitral prosthetic valve; * Subject has a significant mitral valve insufficiency (Effective Regurgitant Orifice (ERO) \> 0.2 cm²) with possibility of mitral valve surgery; * Subject has left ventricular thrombus; * Subject has LV aneurysma or is a candidate for surgical aneurysmectomy; * Subje…