Hypofractionated Adaptive Image-Guided Radiation Therapy for Localized Adenocarcinoma of the Prostate

Inclusion Criteria: * Histologically confirmed, locally confined adenocarcinoma of the prostate * Clinical stages T1a to T2b PSA of less than 10 ng per ml * Gleason score of less than 3+4=7 * The patient has decided to undergo external beam radiation as treatment choice for his prostate cancer * Signed study-specific consent form prior to registration Exclusion Criteria: * Stage T3 to 4 disease * Gleason 4+3=7 or higher score * PSA greater than 10 ng per ml * Clinical or Pathological Lymph node involvement N1 * Evidence of distant metastases M1 * Radical surgery for carcinoma of the prostate * Previous Chemotherapy or pelvic radiation therapy * Previous or concurrent cancers other than basal or squamous cell skin cancers or superficial bladder cancer unless disease free for at least 5 years * History of inflammatory bowel disease * Major medical or psychiatric illness which, in the investigator's opinion, would prevent completion of treatment and would interfere with follow up