Humoral and Cellular Immunity of Low and High-responders After Tick-borne Encephalitis Vaccination

Inclusion Criteria: * Adults (≥18 years) of both sexes without upper age limit * Willingness to sign written informed consent form * Basic vaccination plus one booster (minimum) of TBE-vaccine, Exclusion Criteria: * Age: \< 18 years * Pregnancy or breast feeding * Prior TBE infection * Planned surgery within 2 weeks before/after any scheduled rabies vaccination during the entire study * Concomitant medication: systemic cortisone, immune suppressive therapy 4 weeks before or planned medication during the study * History of autoimmune disease * Drug addiction * Plasma donators * Administration of other vaccines 4 weeks before/after day 0 * Administration of immunoglobulins 6 weeks prior to any vaccination or blood donation during the entire study period * Specific Immune Therapy (Hypo-/Desensibilization) within 14 days before and after the 2 study vaccination doses. * History of any malignant disease 5 years prior to the study entry * Any contraindication for the administration of the TBE- or influenza vaccine according to the manufactures information.