UnknownNot Applicable

Pelvic Fractures and Radiation Therapy for Cervical Cancer

United States239 participantsStarted 2008-11-05

Plain-language summary

The goal of this study is to estimate how often pelvic fractures occur in women treated with radiation therapy for either newly diagnosed or recurrent cervical, endometrial, or vaginal cancer. The study will also estimate the changes in bone mineral density and the changes in the blood that relate to "bone turnover". High bone turnover can weaken bones and make you more likely to break a bone.

Who can participate

SexFEMALE

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Inclusion criteria

✓. Patients with histologically confirmed primary or recurrent cervical , endometrial or vaginal cancer. All stages, grades and histologic subtypes will be eligible except neuroendocrine.
✓. Patients treated with definitive radiation therapy. Patients receiving extended field radiation or brachytherapy in addition to pelvic radiation are eligible. Patients treated with surgery, chemotherapy and/or hormonal therapy in addition to radiation therapy are also eligible.
✓. Patients must sign an approved informed consent document.

Exclusion criteria

✕. Patients undergoing palliative intent radiation therapy for advanced disease.
✕. Patients who received prior radiation to the pelvis.
✕. Patients with an existing pelvic fracture within the proposed radiation field.
✕. Patients unwilling or unable to provide informed consent for the study.
✕. Patients with bone metastases.
✕. Neuroendocrine features present.
✕. Patients weighing more than 300 lbs are excluded as they cannot be adequately studied in axial skeleton with current bone mineral density software.

What they're measuring

Change in Patient Bone Mineral Density (BMD)

Timeframe: 2 years

Trial details

NCT IDNCT00800644

SponsorM.D. Anderson Cancer Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-11-30

View on ClinicalTrials.gov More Cervical Cancer trials