Regulation of Mucosal Immune Response to Systemic MenB Vaccine

Inclusion Criteria: * written informed consent and agreement for samples to be sent overseas * adults and adolescents 16-40 years scheduled to undergo routine tonsillectomy * in good health at the time of entry into the study as determined by medical history, physical examination and clinical judgment of the investigator * availability for all the visits scheduled in the study Exclusion Criteria: * tonsillectomy for allergic conditions * receipt of or intent to immunize with any vaccination (other than influenza vaccine or post-exposure tetanus vaccination) or investigational agents within 50 days prior to enrolment and throughout the study period * previous receipt of any MenB vaccine * chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs (Inhaled and topical steroids will not be allowed.) * history of confirmed or suspected meningococcal infection or close contact with an individual with culture or PCR proven N. meningitidis serogroup B within the previous 60 days * pregnancy (or plans to become pregnant during study)\* or breast feeding * not taking or unwilling to take sufficient measures to avoid pregnancy occurring for the duration of the study period\*\* * any chronic or progressive disease (eg neoplasm, cardiac, respiratory, liver, gastrointestinal, renal, neurological disease, autoimmune disease, blood dyscrasias or diathesis) or history of dependence/abuse of drugs or alcohol • any confirmed or suspected immu…