CompletedPhase 4

Septic Encephalopathy and Late Cognitive Dysfunction

Switzerland50 participantsStarted 2008-10

Plain-language summary

Delirium and long-term cognitive dysfunction are important problems in intensive care patients. Patients with sepsis are at a high risk of developing delirium (septic encephalopathy), which may be an important risk factor for the development of long-term cognitive dysfunction. Working hypotheses: 1. Septic encephalopathy and cognitive dysfunction are caused by an unspecific reaction of the brain to an intense inflammatory stimulus. 2. It is possible to therapeutically influence the inflammatory response and its effects on the brain.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Admitted to an intensive care unit for treatment of sepsis, severe sepsis or septic shock * Age 18 or older Exclusion Criteria: * Primary infection of the CNS * History of cerebrovascular disease * History of any neoplasia involving the CNS * History of long-term psychiatric medication * History of allergy to fish- or egg-protein * Severe coagulation abnormalities * Clinical signs of altered coagulation, active bleeding * Pregnancy

Trial details

NCT IDNCT00772096

SponsorUniversity Hospital, Basel, Switzerland

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-06

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