TerminatedPhase 3

Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome

Stopped: A similar publication has been released, suggesting a beneficial effect of sartans, and only 15 patients remained to be seen for their visit at 36 months.

France303 participantsStarted 2008-09

Plain-language summary

The purpose of this study is to evaluate if losartan limits aortic dilatation in patients with Marfan syndrome.

Who can participate

Age range10 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 10 years or older * Marfan syndrome according to international criteria Signed informed consent Exclusion Criteria: * Previous surgery of the ascending aorta, or surgery planned * Non echogenicity * Contre-indication lactose * Pregnancy on going or planned within 3 years * Breast feeding * Participation in another clinical study * Non member of the social security or CMU

What they're measuring

normalised aortic diameter at the level of the sinus of valsalva

Timeframe: every six months

Trial details

NCT IDNCT00763893

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-01

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