Active — Not RecruitingPhase 2

Intrapleural Catheter Daily Versus Three Times a Week Drainage

United States257 participantsStarted 2008-08-22

Plain-language summary

The goal of this clinical research study is to learn if draining the IPC every day is better at than draining it 3 times a week.

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✕. Any of the following interventions on the affected hemithorax: prior IPC, prior chest tube placement, history of chemical or mechanical pleurodesis, history of thoracotomy within 4 weeks incompletely healed surgical incision before randomization.
✕. Evidence of empyema or history of empyema of the affected hemithorax
✕. Non-correctable bleeding diathesis
✕. Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
✕. Evidence of severe or uncontrolled systemic disease or any concurrent condition which in the Principal Investigator's opinion makes it undesirable for the patient to participate in the trial or which would jeopardize compliance with the protocol.
✕. Participation in any clinical trial that prevents randomization of the subject to either strategy.
✕. Clinical evidence of skin infection at the potential site of IPC placement.
✕. Current or prior IPC placement, or any intervention to manage recurrent malignant pleural effusion on the contralateral hemithorax (excluding thoracentesis).

Time to Pleurodesis (TTP)

Timeframe: 2 weeks after intrapleural catheter placement

NCT IDNCT00761618

SponsorM.D. Anderson Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08-31

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✕. Any of the following interventions on the affected hemithorax: prior IPC, prior chest tube placement, history of chemical or mechanical pleurodesis, history of thoracotomy within 4 weeks incompletely healed surgical incision before randomization.
✕. Evidence of empyema or history of empyema of the affected hemithorax
✕. Non-correctable bleeding diathesis
✕. Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
✕. Evidence of severe or uncontrolled systemic disease or any concurrent condition which in the Principal Investigator's opinion makes it undesirable for the patient to participate in the trial or which would jeopardize compliance with the protocol.
✕. Participation in any clinical trial that prevents randomization of the subject to either strategy.
✕. Clinical evidence of skin infection at the potential site of IPC placement.
✕. Current or prior IPC placement, or any intervention to manage recurrent malignant pleural effusion on the contralateral hemithorax (excluding thoracentesis).