WithdrawnPhase 4

Lipopolysaccharide Binding Protein and Development of Infectious Events in Cirrhotic Patients

Stopped: was not possible to measure LBP levels because we cannot found the kit

Mexico0

Plain-language summary

The purpose of this study is to determine whether plasma levels of lipopolysaccharide binding protein (LBP) are correlated with PBMN pro- and anti-inflammatory cytokine secretion, as well as with the development of severe infectious events in cirrhotic patients with ascites. As a secondary purpose, the study will evaluate the effect of a prophylactic administration of ciprofloxacin on LBP, cytokines and infections in the same patients.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Cirrhosis * Ascites * No history of spontaneous bacterial peritonitis and/or \< 1 g of protein in ascites * No antibiotic use in previous 6 weeks * Absence of infection (documented by clinical history, blood cytology, urinalysis and urine culture, thorax x-ray and paracentesis) * Absence of GI bleeding or encephalopathy * Signature of informed consent Exclusion Criteria: * Ciprofloxacin contraindication * Autoimmune hepatitis, sclerosing cholangitis or other autoimmune disease * \> 13 Child-Pugh points * Inability to attend to regular visits * Current alcohol intake * Terminal disease with \< 24 week expected survival

What they're measuring

Lipopolysaccharide binding protein plasma levels

Timeframe: 24 weeks

Trial details

NCT IDNCT00760032

SponsorFlorencia Vargas-Vorackova

Sponsor typeOTHER

Study typeINTERVENTIONAL

View on ClinicalTrials.gov More Cirrhosis trials