Stopped: Funding ended
RATIONALE: Diagnostic procedures, such as MRI, may help in learning how well radiation therapy and chemotherapy work in killing tumor cells and allow doctors to plan better treatment. PURPOSE: This clinical trial is studying MRI scans to see how well they evaluate the effects of radiation therapy and chemotherapy in patients with newly diagnosed glioblastoma multiforme or anaplastic glioma.
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Relative Cerebral Blood Volume as Measured by Perfusion-weighted MRI Before, During, and After Chemoradiotherapy
Timeframe: Baseline, weekly during treatment, monthly following treatment for up to six months
Relative Cerebral Blood Flow as Measured by Perfusion-weighted MRI Before, During, and After Chemoradiotherapy
Timeframe: Baseline, weekly during treatment, monthly following treatment for up to six months
Vessel Diameter as Measured by Perfusion-weighted MRI Before, During, and After Chemoradiotherapy
Timeframe: Baseline, weekly during treatment, monthly following treatment for up to six months
Mean Transit Time as Measured by Perfusion-weighted MRI Before, During, and After Chemoradiotherapy
Timeframe: Baseline, weekly during treatment, monthly following treatment for up to six months
Permeability-surface Area Product Before, During, and After Chemoradiotherapy
Timeframe: Baseline, weekly during treatment, monthly following treatment for up to six months
Apparent Diffusion Coefficient Before, During, and After Chemoradiotherapy
Timeframe: Baseline, weekly during treatment, monthly following treatment for up to six months
Tensor Fractional Anisotropy Before, During, and After Chemoradiotherapy
Timeframe: Baseline, weekly during treatment, monthly following treatment for up to six months
Relative Regional Concentrations of Choline, N-acetyl-asparate, and Myoinositol as Measured by Magnetic Resonance Spectroscopy Before, During, and After Chemoradiotherapy to Interrogate Cell Membrane Turnover, Neuronal Integrity, and Glial Reactions
Timeframe: Baseline, weekly during treatment, monthly following treatment for up to six months
Affects of a Short Period of 100% Oxygen Inhalation on Imaging of Tumor and Surrounding Tissue Regions of Interest, Specifically Cerebral Blood Volume Changes in Each Area as Compared to Room Air
Timeframe: Baseline, weekly during treatment, monthly following treatment for up to six months