Study of CryoSpray Ablation(TM)to Determine Treatment Effect, Depth of Injury, and Side Effects in the Esophagus.

Inclusion Criteria: * Age 18 years of age * Esophagectomy planned based on clinical situation not related to this study. * Deemed operable based on institutional criteria. Exclusion Criteria: * Pregnant * Esophageal stricture preventing passage of endoscope or catheter. * Known history of unresolved drug or alcohol dependency that would limit ability to comprehend or follow instructions related to informed consent, post-treatment instructions, or follow-up guidelines. * Refusal or inability to give consent. * Concurrent chemotherapy. * Prior or concurrent endoscopic ablation therapy within 4 cm from the CSA treatment area including, but not limited to, cryospray therapy, laser treatment, photodynamic therapy, multi-polar electro coagulation, endoscopic mucosal resection, radiofrequency ablation, or argon plasma coagulation. * Prior radiation therapy which involved the esophagus.