Pharmacokinetics of Caspofungin in Burn Patients

Inclusion Criteria: * 18 - 60 years old * burn surface : 20-60% total body surface area * delay of injury time : 8-15 days * lack of fungal infection * delay of hospitalization : \> 5 days * written informed consent * last biological picture in 24 hours before inclusion Exclusion Criteria: * survival inferior to 5 days * surgical intervention planned in the next five days following inclusion * moderate or severe hepatic impairment according to Child Plug B \> 9 * pregnancy * allergy to caspofungin or excipients (saccharose, mannitol and frozen acetic acid) * patient already included in other study * concomitant administration of CYP450 inducers : rifampicin, efavirenz, phenobarbital, phenytoin, carbamazepine * withdrawal of consent * event (during the first 48 hours following administration) susceptible to modify pharmacokinetic parameters * Investigator decision * no social security insurance