Juvista in Scar Revision Surgery of Disfiguring Scars

Inclusion Criteria: * Patients aged 18-85 years who have provided written informed consent. * BMI between 15 and 35 kg/m2 * Patients with, in the opinion of the Investigator, clinically acceptable results for the laboratory tests specified in the trial protocol. * If females of child bearing potential, patients must be using a highly effective method(s) of contraception and agree to do so from at least the screening visit until one month after administration of the final study dose. * The scar area to be revised is disfiguring. To be considered disfiguring for this trial scars must have at least one of the following characteristics. * Scar area 13 or more cm in length. * Scar area at least 0.6 cm wide at widest part. * Surface contour of scar area elevated or depressed on palpation. * Scar area adherent to underlying tissue. * Skin hypo-or hyper-pigmented in an area exceeding 39cm2. * Skin texture abnormal (irregular, atrophic, shiny, scaly, etc.) in an area exceeding 39cm2. * The scar to be revised is at least 12 months old. * The investigator considers that the appearance of the scar area to be revised can be improved with surgery alone. * The scar area is linear and suitable for revision by excision and direct closure. * The scar area to be revised is symmetrical in appearance around the mid-line. * The scar area to be revised is between 7 and 20cm in length. * The scar area to be revised runs along a flat surface which is in the same focal plane and suitable for accurate…