CompletedPhase 1/2

Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) Patients

Iran10 participantsStarted 2007-10

Plain-language summary

The purpose of this study is to evaluate the efficacy, safety, and long term outcomes of ex vivo cultured limbal stem cell on amniotic membrane transplantation for corneal surface reconstruction in cases of partial and sever limbal stem cell deficiency.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient with unilateral limbal stem cell insufficiency and totally corneal vascularization * Presence of Goblet cells on the cornea * Minimum tear was about 5 mm * Minimum duration of deficiency was 3 years * Vision was Light Perception Exclusion Criteria: * Systemic disease affecting both eyes such as Stevens-Johnson syndrome

What they're measuring

Snellen visual acuity

Timeframe: 6 months

corneal epithelial integrity and stability

Timeframe: 6 months

Trial details

NCT IDNCT00736307

SponsorRoyan Institute

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2009-07

View on ClinicalTrials.gov More Limbal Stem Cell Deficiency trials