CompletedPhase 2/3

Clinical Neurobiology of Serotonin and Addiction

United States160 participantsStarted 2008-06

Plain-language summary

The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on impulsivity and cue reactivity in human cocaine users.

Who can participate

Age range18 Years – 55 Years

SexALL

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Exclusion criteria

✕. Current or past DSM-IV Axis I disorder
✕. Any serious non-psychiatric medical illness requiring ongoing medical treatment or which could affect the central nervous system.
✕. Positive HIV test.
✕. For female subjects: a positive pregnancy test or breast feeding.
✕. Concomitant use of prescription medications that could affect the central nervous system.
✕. Active suicidal ideation.
✕. Hamilton Depression or Anxiety Scale score greater than 15
✕. Current DSM-IV Axis I disorder other than substance abuse/dependence

What they're measuring

Immediate Memory Task

Timeframe: after acute dose and after chronic administration

Trial details

NCT IDNCT00732901

SponsorVirginia Commonwealth University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2013-02

Results submitted2016-07-20

View on ClinicalTrials.gov More Cocaine Dependence trials