CompletedPhase 4

The Effect of Protein on Calcium Absorption and Gastric Acid Production

United States12 participantsStarted 2005-01

Plain-language summary

We have established that dietary protein is an important regulator of intestinal calcium absorption in humans. However, we do not understand the mechanism by which dietary protein is affecting calcium absorption. Therefore, the purpose of this research is to evaluate whether dietary protein-induced changes in gastric acid secretion explain the observed changes in intestinal calcium absorption.

Who can participate

Age range18 Years – 45 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy men and women age 18-45 years * Caucasian or Asian descent due to increased risk of Osteoporosis Exclusion Criteria: * gastrointestinal diseases * osteoporosis * diabetes * hypertension * liver disease * thyroid disorders * kidney disease * kidney stones * cancer * heart disease * eating disorders * obesity * hypogonadism * amenorrhea * oligomenorrhea * abnormal serum FSH or estradiol levels * birth control medication or other hormone-altering medications * pregnancy * Lifestyle factors such as: * smoking * excessive exercise (although moderate exercise is allowed) * prescription medications known to influence vitamin D or calcium metabolism or gastric acid * excessive body weight change during the past 6 months * food allergies * unusual eating habits or medically prescribed diets

What they're measuring

Percent Change in Intestinal Calcium Absorption

Timeframe: Day 5 of a high protein diet

Trial details

NCT IDNCT00719160

SponsorYale University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-05

Results submitted2012-01-26

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